The spectrum of cognitive disorders in Parkinson's disease: A data‐driven approach
Identifieur interne : 000E16 ( Main/Exploration ); précédent : 000E15; suivant : 000E17The spectrum of cognitive disorders in Parkinson's disease: A data‐driven approach
Auteurs : Kathy Dujardin [France] ; Albert F. G. Leentjens [Pays-Bas] ; Carole Langlois [France] ; Anja J. H. Moonen [Pays-Bas] ; Annelien A. Duits [Pays-Bas] ; Anne-Sophie Carette [France] ; Alain Duhamel [France]Source :
- Movement Disorders [ 0885-3185 ] ; 2013-02.
English descriptors
- KwdEn :
- Adult, Age Factors, Age of Onset, Aged, Cluster Analysis, Cognition (physiology), Cognition Disorders (epidemiology), Cognition Disorders (etiology), Cognition Disorders (psychology), Data Interpretation, Statistical, Educational Status, Europe (epidemiology), Female, Humans, Male, Memory Disorders (etiology), Memory Disorders (psychology), Middle Aged, Models, Statistical, Neuropsychological Tests, Parkinson Disease (complications), Parkinson Disease (epidemiology), Parkinson Disease (psychology), Phenotype, Recognition (Psychology), Socioeconomic Factors.
- MESH :
- geographic , epidemiology : Europe.
- complications : Parkinson Disease.
- epidemiology : Cognition Disorders, Parkinson Disease.
- etiology : Cognition Disorders, Memory Disorders.
- physiology : Cognition.
- psychology : Cognition Disorders, Memory Disorders, Parkinson Disease.
- Adult, Age Factors, Age of Onset, Aged, Cluster Analysis, Data Interpretation, Statistical, Educational Status, Female, Humans, Male, Middle Aged, Models, Statistical, Neuropsychological Tests, Phenotype, Recognition (Psychology), Socioeconomic Factors.
Abstract
The objective of this study was to identify different cognitive phenotypes in Parkinson's disease (PD) using a data‐driven approach. A model‐based cluster analysis was conducted on the neuropsychological test results of 558 PD patients from 2 European movement disorder centers (Lille, n = 403; Maastricht, n = 155). The number of clusters was determined according to their clinical relevance as well as on the basis of 3 statistical criteria: the cubic cluster criterion, the pseudo F statistic, and the total squared correlation ratio (R2). A factorial discriminant analysis was performed to assess the quality of the cluster's separation. Descriptive variables were used to further characterize the clusters. A 5‐cluster model was considered the clinically most relevant. The 5 clusters comprised: (1) cognitively intact patients (19.39%); (2) patients without cognitive deficits but with slight mental slowing (41.29%); (3) patients with slightly impaired overall cognitive efficiency and deficits in all cognitive domains except recognition memory (12.93%); (4) patients with severe mental slowing, impaired overall cognitive efficiency, and severe cognitive impairment in all domains, including memory (23.88%); and (5) patients with very severe impairment in all cognitive domains (2.51%). Cognitively intact patients were significantly younger and had received more years of formal education. Patients in the last 3 clusters had more severe motor symptoms, longer disease duration, and more axial signs. In the last cluster, most patients were demented. Our results confirm the heterogeneity of cognitive presentations in PD, ranging from cognitively intact patients with rather high levels of performance in each cognitive domain to very severely impaired patients. © 2013 Movement Disorder Society
Url:
DOI: 10.1002/mds.25311
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001C25
- to stream Istex, to step Curation: 001C23
- to stream Istex, to step Checkpoint: 000023
- to stream PubMed, to step Corpus: 000778
- to stream PubMed, to step Curation: 000745
- to stream PubMed, to step Checkpoint: 000745
- to stream Ncbi, to step Merge: 001082
- to stream Ncbi, to step Curation: 001082
- to stream Ncbi, to step Checkpoint: 001082
- to stream Main, to step Merge: 000E44
- to stream Main, to step Curation: 000E16
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">The spectrum of cognitive disorders in Parkinson's disease: A data‐driven approach</title><author><name sortKey="Dujardin, Kathy" sort="Dujardin, Kathy" uniqKey="Dujardin K" first="Kathy" last="Dujardin">Kathy Dujardin</name></author><author><name sortKey="Leentjens, Albert F G" sort="Leentjens, Albert F G" uniqKey="Leentjens A" first="Albert F. G." last="Leentjens">Albert F. G. Leentjens</name></author><author><name sortKey="Langlois, Carole" sort="Langlois, Carole" uniqKey="Langlois C" first="Carole" last="Langlois">Carole Langlois</name></author><author><name sortKey="Moonen, Anja J H" sort="Moonen, Anja J H" uniqKey="Moonen A" first="Anja J. H." last="Moonen">Anja J. H. Moonen</name></author><author><name sortKey="Duits, Annelien A" sort="Duits, Annelien A" uniqKey="Duits A" first="Annelien A." last="Duits">Annelien A. Duits</name></author><author><name sortKey="Carette, Anne Ophie" sort="Carette, Anne Ophie" uniqKey="Carette A" first="Anne-Sophie" last="Carette">Anne-Sophie Carette</name></author><author><name sortKey="Duhamel, Alain" sort="Duhamel, Alain" uniqKey="Duhamel A" first="Alain" last="Duhamel">Alain Duhamel</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:DE229B12E504E954F5071EB3AF46F88B6A66DB3E</idno><date when="2013" year="2013">2013</date><idno type="doi">10.1002/mds.25311</idno><idno type="url">https://api.istex.fr/document/DE229B12E504E954F5071EB3AF46F88B6A66DB3E/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001C25</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001C25</idno><idno type="wicri:Area/Istex/Curation">001C23</idno><idno type="wicri:Area/Istex/Checkpoint">000023</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000023</idno><idno type="wicri:doubleKey">0885-3185:2013:Dujardin K:the:spectrum:of</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:23436633</idno><idno type="wicri:Area/PubMed/Corpus">000778</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000778</idno><idno type="wicri:Area/PubMed/Curation">000745</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000745</idno><idno type="wicri:Area/PubMed/Checkpoint">000745</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000745</idno><idno type="wicri:Area/Ncbi/Merge">001082</idno><idno type="wicri:Area/Ncbi/Curation">001082</idno><idno type="wicri:Area/Ncbi/Checkpoint">001082</idno><idno type="wicri:Area/Main/Merge">000E44</idno><idno type="wicri:Area/Main/Curation">000E16</idno><idno type="wicri:Area/Main/Exploration">000E16</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">The spectrum of cognitive disorders in Parkinson's disease: A data‐driven approach</title><author><name sortKey="Dujardin, Kathy" sort="Dujardin, Kathy" uniqKey="Dujardin K" first="Kathy" last="Dujardin">Kathy Dujardin</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Neurosciences Fonctionnelles et Pathologies, University of Lille 2, EA4559, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Neurology and Movement Disorders Department, Lille University Medical Center, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">France</country></affiliation></author><author><name sortKey="Leentjens, Albert F G" sort="Leentjens, Albert F G" uniqKey="Leentjens A" first="Albert F. G." last="Leentjens">Albert F. G. Leentjens</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Psychiatry, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Langlois, Carole" sort="Langlois, Carole" uniqKey="Langlois C" first="Carole" last="Langlois">Carole Langlois</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Department of Biostatistics, Lille University Medical Center, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Moonen, Anja J H" sort="Moonen, Anja J H" uniqKey="Moonen A" first="Anja J. H." last="Moonen">Anja J. H. Moonen</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Psychiatry, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Duits, Annelien A" sort="Duits, Annelien A" uniqKey="Duits A" first="Annelien A." last="Duits">Annelien A. Duits</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Psychiatry, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Carette, Anne Ophie" sort="Carette, Anne Ophie" uniqKey="Carette A" first="Anne-Sophie" last="Carette">Anne-Sophie Carette</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Neurology and Movement Disorders Department, Lille University Medical Center, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Duhamel, Alain" sort="Duhamel, Alain" uniqKey="Duhamel A" first="Alain" last="Duhamel">Alain Duhamel</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Department of Biostatistics, Lille University Medical Center, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><date type="published" when="2013-02">2013-02</date><biblScope unit="volume">28</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="183">183</biblScope><biblScope unit="page" to="189">189</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">DE229B12E504E954F5071EB3AF46F88B6A66DB3E</idno><idno type="DOI">10.1002/mds.25311</idno><idno type="ArticleID">MDS25311</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Age Factors</term><term>Age of Onset</term><term>Aged</term><term>Cluster Analysis</term><term>Cognition (physiology)</term><term>Cognition Disorders (epidemiology)</term><term>Cognition Disorders (etiology)</term><term>Cognition Disorders (psychology)</term><term>Data Interpretation, Statistical</term><term>Educational Status</term><term>Europe (epidemiology)</term><term>Female</term><term>Humans</term><term>Male</term><term>Memory Disorders (etiology)</term><term>Memory Disorders (psychology)</term><term>Middle Aged</term><term>Models, Statistical</term><term>Neuropsychological Tests</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (epidemiology)</term><term>Parkinson Disease (psychology)</term><term>Phenotype</term><term>Recognition (Psychology)</term><term>Socioeconomic Factors</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Europe</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Cognition Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term><term>Memory Disorders</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cognition</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Cognition Disorders</term><term>Memory Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Age Factors</term><term>Age of Onset</term><term>Aged</term><term>Cluster Analysis</term><term>Data Interpretation, Statistical</term><term>Educational Status</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Models, Statistical</term><term>Neuropsychological Tests</term><term>Phenotype</term><term>Recognition (Psychology)</term><term>Socioeconomic Factors</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">The objective of this study was to identify different cognitive phenotypes in Parkinson's disease (PD) using a data‐driven approach. A model‐based cluster analysis was conducted on the neuropsychological test results of 558 PD patients from 2 European movement disorder centers (Lille, n = 403; Maastricht, n = 155). The number of clusters was determined according to their clinical relevance as well as on the basis of 3 statistical criteria: the cubic cluster criterion, the pseudo F statistic, and the total squared correlation ratio (R2). A factorial discriminant analysis was performed to assess the quality of the cluster's separation. Descriptive variables were used to further characterize the clusters. A 5‐cluster model was considered the clinically most relevant. The 5 clusters comprised: (1) cognitively intact patients (19.39%); (2) patients without cognitive deficits but with slight mental slowing (41.29%); (3) patients with slightly impaired overall cognitive efficiency and deficits in all cognitive domains except recognition memory (12.93%); (4) patients with severe mental slowing, impaired overall cognitive efficiency, and severe cognitive impairment in all domains, including memory (23.88%); and (5) patients with very severe impairment in all cognitive domains (2.51%). Cognitively intact patients were significantly younger and had received more years of formal education. Patients in the last 3 clusters had more severe motor symptoms, longer disease duration, and more axial signs. In the last cluster, most patients were demented. Our results confirm the heterogeneity of cognitive presentations in PD, ranging from cognitively intact patients with rather high levels of performance in each cognitive domain to very severely impaired patients. © 2013 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>France</li><li>Pays-Bas</li></country><region><li>Hauts-de-France</li><li>Nord-Pas-de-Calais</li></region><settlement><li>Lille</li></settlement></list><tree><country name="France"><region name="Hauts-de-France"><name sortKey="Dujardin, Kathy" sort="Dujardin, Kathy" uniqKey="Dujardin K" first="Kathy" last="Dujardin">Kathy Dujardin</name></region><name sortKey="Carette, Anne Ophie" sort="Carette, Anne Ophie" uniqKey="Carette A" first="Anne-Sophie" last="Carette">Anne-Sophie Carette</name><name sortKey="Duhamel, Alain" sort="Duhamel, Alain" uniqKey="Duhamel A" first="Alain" last="Duhamel">Alain Duhamel</name><name sortKey="Dujardin, Kathy" sort="Dujardin, Kathy" uniqKey="Dujardin K" first="Kathy" last="Dujardin">Kathy Dujardin</name><name sortKey="Dujardin, Kathy" sort="Dujardin, Kathy" uniqKey="Dujardin K" first="Kathy" last="Dujardin">Kathy Dujardin</name><name sortKey="Langlois, Carole" sort="Langlois, Carole" uniqKey="Langlois C" first="Carole" last="Langlois">Carole Langlois</name></country><country name="Pays-Bas"><noRegion><name sortKey="Leentjens, Albert F G" sort="Leentjens, Albert F G" uniqKey="Leentjens A" first="Albert F. G." last="Leentjens">Albert F. G. Leentjens</name></noRegion><name sortKey="Duits, Annelien A" sort="Duits, Annelien A" uniqKey="Duits A" first="Annelien A." last="Duits">Annelien A. Duits</name><name sortKey="Moonen, Anja J H" sort="Moonen, Anja J H" uniqKey="Moonen A" first="Anja J. H." last="Moonen">Anja J. H. Moonen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000E16 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000E16 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:DE229B12E504E954F5071EB3AF46F88B6A66DB3E
|texte= The spectrum of cognitive disorders in Parkinson's disease: A data‐driven approach
}}
| This area was generated with Dilib version V0.6.29. |  |